Asp.Net Ajax 1.0 goes odd with MapXtreme 2005 6.6

I put a scriptmanager and updatepanel in my web gis application base on MapXtreme 2005 6.6; everytime I click the contols in the updatepanel the web browser will refresh the whole web page which is odd for Asp.Net Ajax 1.0.

Then I put the same scriptmanager and updatepanel and my own controls into another web page without MapXtreme 2005 6.6, it goes exactly the way I want. But I wonder Asp.Net Ajax 1.0 FrameWork should work right in every asp.net web page with any web controls outside the updatepanels

Have you create AJAX Enabled Web Site...

Check the property of ScriptManager EnablePartialRendering="true" and for UpdatePanel UpdateMode="Conditional"